The key fields of investigation are:. Skip to main content. Additional info Profile The key fields of investigation are: Precision Electroceuticals Top10Tech by World Economic Forum personalized neuromodulation, home treatments, clinical biomarkers, tailored therapy, telemedicine, hybrid technology, wearable communication devices, electrophysiologymagneto- and electro-encephalography and electromyography MEG, EEG, EMGfractal dimension, Functional Source Separation FSSfeedback-synchrony-plasticity, morphology, transcranial magnetic and electric stimulation TMS, tES with transcranial Individual neuroDynamics Stimulation, tIDSfatigue, stroke, depression, multiple sclerosis, epilepsy.

Franca Tecchio. Publication Date -Year Source: Neural Plasticity Print Cortical neurodynamics changes mediate the efficacy of a personalized neuromodulation against multiple sclerosis fatigue. Source: Scientific reports Nature Publishing Group 9 Longitudinal quantitative electroencephalographic study in mono-hemispheric stroke patients.

Source: Neural Regeneration Research 14 : — Neuronal dynamics enable the functional differentiation of resting state networks in the human brain.

Source: Human brain mapping Print The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study.

Source: Clinical EEG and neuroscience 2 Source: The Journal of neuroscience 38 : — Source: Frontiers in neural circuits 12 Source: International journal of neural systems 28 MRI-guided regional personalized electrical stimulation in multisession and home treatments. Source: Frontiers in neuroscience Print 12 Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. Source: Multiple sclerosis 24 : — Prognostic value of serum copper for post-stroke clinical recovery: A pilot study.

Source: Frontiers in neurology 9 Vecchio, F. Source: Neurorehabilitation and neural repair 31 : 56— Mayhew, Stephen D. Source: NeuroImage Orlando Fla. Simple index of functional connectivity at rest in Multiple Sclerosis fatigue.Our ultimate goal is to develop translational neuroscience research at all levels. One goal of the CTN is to effectively translate new knowledge, mechanisms, and techniques generated by advances in basic science research into new approaches for prevention, diagnosis, and treatment of disease.

We have been very successful in this T1 aim. A second goal T2 is to improve access, coordinate systems of care, and help clinicians and patients make more informed choices, providing point-of-care decision support tools, and strengthening the patient physician relationship.

Both goals are aimed at improving the health of our citizens. We currently support laboratory research molecular, cellular, organpre-clinical research, are beginning to study medical and behavioral outcomes, and have solid experience in community based research and outreach. Therefore, we established the capacity for recording the midlatency auditory P50 evoked potential, whose amplitude is a measure of level of arousal and thus assesses brainstem-thalamus processes 5.

The use of paired auditory stimuli allows us to measure habituation to repetitive stimulation, or sensory gating, a process disturbed in a number of diseases 5. We also developed the capacity to measure reaction time RT using a Psychomotor Vigilance Task 6 to derive the prototypical measure of attention and thalamocortical processes 7.

We developed the capacity to measure frontal lobe blood flow using near infrared spectroscopy, which provides an economical indicator for the use of more expensive methods such as PET. We established a satellite facility for spinal reflex testing in spinal cord injury and other patient populations.

A separate room contains an animal reflex testing set-up to allow parallel studies on humans and animal with spinal cord injury and other motor disorders. We set up multiple patch-clamp rigs with immersion and interface chambers, and a full surgical facility is also part of this Core. We have expanded our capabilities to include voltage-sensitive dye and calcium imaging at high speed and at high resolution.

As the equipment aged, we upgraded the human facility and used the older equipment to develop our capacity to use TMS on animals in the Animal Electrophysiology Core.

It includes chambers for assessing, in rats and mice, locomotion, conditioned place preference, and prepulse inhibition. A new Noldus EthoVision system was added for video tracking and activity measures, while a CatWalk system was purchased for gait analysis and detailed locomotion analyses. Weekly telemedicine conferences on perinatology allow our community of health care personnel, including physicians, nurses and therapists, to participate live, to gain continuing medical education CME credit, and to help develop therapeutic and other guidelines.

Consultations follow the educational conferences and help form collaborative relationships, provide better care for rural and underserved populations, and lead to more organized transfers and referrals. The Telemedicine Core Facility of the CTN is a shared resource that provides access to training, consultation, services, instruments, and technology for translational community-based research.

The CTN remains one of the few COBREs designed to increase the number of clinician scientists to become independent researchers, with a focus on human subject research. We will facilitate the optimization of our community-based Telemedicine Core Facility, which has already decreased infant mortality across the state, to collaborate with the CTR in Oklahoma OK that will bring about a decrease in mortality in this adjacent IDeA state.

We propose, a to develop training courses to optimize the implementation of our Peds PLACE and D-TRACE programs to decrease mortality from sub-optimal neonatal and emergency services with special emphasis on the health care delivery community, b enhance communication and collaboration across regional IDeA states, initially, OK, but easily expandable to other regions and then nationally, c provide the National IDeA Core Laboratory NICL with decreased mortality data to help implement the Core Facility across all IDeA states, and d to help create, expand, and sustain this critical resource across IDeA states.

Every year from now on. We began inand significantly decreased mortality byand levels continue to decline. We have also identified a program likely to decrease mortality from suboptimal emergency health coverage for underprivileged areas of the state. Non-trained public safety answering point PSAP operators do not provide enough medical priority dispatch system MPDS determinants on medical calls and risk delayed emergency service response time, jeopardizing patient safety.

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High mortality rates due to stroke, myocardial infarction, and trauma will be reduced statewide by adequately training rural dispatchers. Using a novel, phone app-based training program, PSAP personnel in underserved rural areas will provide better determinants, improve health care coverage, and decrease mortality.Our researchers engage in a wide variety of experimental approaches. At human research labs these include statistical and mathematical modeling, electrophysiology, and brain imaging.

Our primary goal is to prepare outstanding scholars and researchers. Dennis Millerbiological basis of pain and anxiety. Todd Schachtmanneuroscience: conditioning and retention; Alzheimer's; diet; spatial cognition. Matthew Willneural regulation of motivation and reward. David Beversdorfneuropsychopharmacology and prenatal stress in autism; stress, creativity and neuroimaging.

Simple index of functional connectivity at rest in Multiple Sclerosis fatigue

Nelson Cowanworking memory, short-term memory, attention, and their childhood development. Jeff Johnsoncognitive and neural basis of episodic memory. Steve Hackleycognitive neuroscience of attention and action. Moshe Naveh-Benjaminhuman memory processes including adult-age changes in episodic memory and the interplay between attention and memory. Shawn Christcognitive and neural processes underlying typical and atypical development.

Scott Freyneuroplasticity and evidence-based rehabilitation. Skip to main content. Cognition and Neuroscience. Coronal for Cognition and Neuroscience. Dennis K. Event-related potentials ERPsstartle-blink, and neuroimaging techniques are used to identify the locus and time course of relevant brain processes in normal and neurologically impaired adults.

Steven A.

laboratory of electrophysiology for translational neuroscience

Hackley Psychology Building Cognition, Aging, Sleep, and Health Lab Ashley Curtis Cognitive Neuroscience Lab Our lab is currently involved in research on autism, dementia, cognitive effects of stress, the cognitive neuroscience of problem solving ability, functional neuroimaging, and pharmacological modulation of cognition.

The Health Neuroscience Center HNC is organized around using cognitive and affective neuroscience methods to investigate the pathophysiology of drug addiction and neuropsychiatric disorders. Our goal is to provide a bridge between preclinical and clinical trials research in order to better understand the etiology of dyregulated behavior and the effectiveness of new treatment that may ultimately be used in the clinic.

We are currently conducting research in nicotine addiction and opioid use disorder; and examining the effects of novel pharmacological, non-invasive neural stimulation and behavioral-based treatments for substance use disorders. Each research project is conducted using human subjects and leverages a broad array of techniques including fMRI brain imaging, lab-based behavioral measures and remote behavioral monitoring and assessments.

The HNC invites students, fellows and faculty to discuss ways to collaborate on mind-blowing research that may hold potential to reduce human suffering and improve well-being.

laboratory of electrophysiology for translational neuroscience

Brett Froeliger 15 Melvin H.Deep brain stimulation DBS represents one of the major clinical breakthroughs in the age of translational neuroscience. InBenabid and colleagues demonstrated that high-frequency stimulation can mimic the effects of ablative neurosurgery in Parkinson's disease PDwhile offering two key advantages to previous procedures: adjustability and reversibility. Deep brain stimulation is now an established therapeutic approach that robustly alleviates symptoms in patients with movement disorders, such as Parkinson's disease, essential tremor, and dystonia, who present with inadequate or adverse responses to medication.

Currently, stimulation electrodes are implanted in specific target regions of the basal ganglia-thalamic circuit and stimulation pulses are delivered chronically. To achieve optimal therapeutic effect, stimulation frequency, amplitude, and pulse width must be adjusted on a patient-specific basis by a movement disorders specialist.

The goal of this strategy is to identify pathological and physiologically normal patterns of neuronal activity that can be used to adapt stimulation parameters to the concurrent therapeutic demand. This review will give detailed insight into potential biomarkers and discuss next-generation strategies, implementing advances in artificial intelligence, to further elevate the therapeutic potential of DBS by capitalizing on its modifiable nature.

Cognition and Neuroscience

Development of intelligent aDBS, with an ability to deliver highly personalized treatment regimens and to create symptom-specific therapeutic strategies in real-time, could allow for significant further improvements in the quality of life for movement disorders patients with DBS that ultimately could outperform traditional drug treatment.

Abstract Deep brain stimulation DBS represents one of the major clinical breakthroughs in the age of translational neuroscience. Publication types Research Support, N. Gov't Review.From basic neuroscience research to novel therapies, we are improving the lives of patients with degenerative, vascular and inflammatory disorders of the nervous system. The goal of our research is to harness scientific developments emerging from experimental work in the laboratory and translate these insights into effective therapies and better outcomes for patients in the clinical care setting.

We also bring what we learn from patients back to the laboratory to enhance our understanding. Motor neurone disease shares multiple commonalities with other neurodegenerative diseases and is an excellent model for evaluating all forms of neuroprotective treatment. We host teams working on:.

The institute has strong research programmes, including international collaborations — from pre-clinical models through to new drug therapies and other interventions for patients. Our teams have key skills in cellular and molecular biology, in vitro and in vivo disease modelling, human neuropathology, viral vector technology, genetics, pharmacology, gene therapy, RNA processing, electrophysiology, together with experience in clinical research and conducting clinical trials.

Sheffield Biomedical Research Centre. The Neuroscience Institute gives us a new opportunity to build on the existing expertise and advances within SITraN and apply them to a wider community of academic excellence tackling a broader range of diseases.

Sheffield Institute for Translational Neuroscience. Coronavirus Covid : latest advice. Neuroscience Institute. Translational neuroscience. Our multidisciplinary expertise Motor neurone disease shares multiple commonalities with other neurodegenerative diseases and is an excellent model for evaluating all forms of neuroprotective treatment.Skip to search form Skip to main content You are currently offline.

Some features of the site may not work correctly. Shyamsunder and Bhanu Prasad.

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ShyamsunderBhanu Prasad. Translational Neuroscience is a fundamental laboratory research relating to brain structure and function to advancements of new therapies for neurodevelopmental diseases, neuropsychiatric and neurodegenerative diseases.

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Translational neuroscience

Axonal ion channels from bench to bedside: A translational neuroscience perspective. View 1 excerpt, references background. Research Feed. Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Quality of Life in Patients with Neurodegenerative Diseases. Zebrafish models for translational neuroscience research: from tank to bedside.

laboratory of electrophysiology for translational neuroscience

Related Papers. Abstract Topics References Related Papers. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.Using a multi-modal approach spanning different levels of analyses e.

This information will be critical for developing better treatments, identifying individuals at increased risk for depression, and uncovering markers that could be used to guide treatment selection. Anhedonia—the loss of pleasure or lack of reactivity to reward—is one of the core symptoms of depression, and has been considered a potential trait marker related to vulnerability to depression.

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Surprisingly few studies have utilized laboratory-based measures to objectively characterize anhedonia. The overarching goal of this line of research is to employ a variety of techniques, including electroencephalography EEGevent-related potentials ERPfunctional magnetic resonance imaging fMRImolecular genetics, as well as psychological and pharmacological manipulations to advance our understanding of the neurobiological substrates of anhedonia.

Admon, R. Dopaminergic enhancement of striatal response to reward in major depression. American Journal of Psychiatry, Corticostriatal pathways contribute to the natural time course of positive mood.

Nature Communications. Auerbach, R. Neuroanatomical prediction of anhedonia in adolescents. Neuropsychopharmacology, 42, Der-Avakian, A. Jr, Pizzagalli, D. Psychopharmacology, Kaiser, R. Frontostriatal and dopamine markers of individual differences in reinforcement learning: A multi-modal investigation. Cerebral Cortex.

Dr. Krystal - What is Translational Neuroscience?

Pechtel, P. Disrupted reinforcement learning and maladaptive behavior in women with a history of childhood sexual abuse: A high-density event-related potential study. JAMA Psychiatry, 70, Pizzagalli, D.

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Reduced caudate and nucleus accumbens response to rewards in unmedicated subjects with Major Depressive Disorder. Depression, stress, and anhedonia: Toward a synthesis and integrated model.

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Annual Review of Clinical Psychology, 10, This information will be critical for developing better treatments and for identifying individuals at increased risk for depression. Our research has shown that there are specific patterns of brain activation that correspond to individual differences in treatment response, depression severity, anxiety symptoms, and phenotypes of depression. This line of work relies on an integration of various neuroimaging approaches, including electroencephalography EEG ; functional and structural magnetic resonance imaging fMRI ; and positron emission tomography PET.

Large-scale network dysfunction in Major Depressive Disorder: Meta-analysis of resting-state functional connectivity. JAMA Psychiatry, 72, Kumar, P. Impaired reward prediction error encoding and striatal-midbrain connectivity in depression. Neuropsychopharmacology, 43, Treadway, M.

laboratory of electrophysiology for translational neuroscience

Illness progression, recent stress and morphometry of hippocampal subfields and medial prefrontal cortex in Major Depression. Biological Psychiatry, 77, Webb, C.